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1996-03-09
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Document 0031
DOCN M9650031
TI Simian immunodeficiency virus variants: threat of new lentiviruses.
DT 9605
AU McClure HM; Novembre FJ; Yerkes Regional Primate Research Center, Emory
University,; Atlanta, Georgia 30322, USA.
SO Am J Med Sci. 1996 Jan;311(1):30-3. Unique Identifier : AIDSLINE
MED/96164689
AB Infection in humans with the lentivirus HIV-1 typically results in the
development of a chronic disease state characterized by the slow decline
of CD4+ lymphocytes, the development of immunosuppression, and the
development of opportunistic infections, ultimately leading to death.
Although the average course of disease runs approximately 10 years,
shorter and longer progression times have been noted. These alterations
are presumed to be, at least partially, a factor of viral variation. The
simian immunodeficiency viruses (SIVs) are the nonhuman primate
counterparts to HIV. Several of these isolates, including SIV from sooty
mangabey monkeys, induce a remarkably similar disease in Asian macaques.
Recently, variants of SIV from sooty mangabey monkeys and SIV from
African green monkeys have been described, which are increasingly more
pathogenic. As in HIV-1 infections, this is probably due to genetic
variation. On the basis of these findings, atypical viruses with
tremendous pathogenic potential can arise from apathogenic or moderately
pathogenic viruses.
DE Acquired Immunodeficiency Syndrome/VIROLOGY Animal Cercocebus atys
Cercopithecus aethiops Comparative Study Human HIV-1 Lentivirus
Infections/*VETERINARY Macaca *Primate Diseases Primates Simian
Acquired Immunodeficiency Syndrome/*PHYSIOPATHOLOGY Support, U.S.
Gov't, P.H.S. SIV/*GENETICS/ISOLATION & PURIF/PATHOGENICITY Variation
(Genetics) JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).